Newer aspects of carnitine metabolism in uremia.
نویسندگان
چکیده
New knowledge on the physiologic role of L-carnitine and on the rationale of its use in patients on maintenance hemodialysis is provided. In particular, carnitine normalizes plasma and muscle carnitine levels and modifies both enzymatic pattern of muscle and morphology of single fibers, improving exercise tolerance. In addition, carnitine reduces erythropoietin requirements, the number of hypotensive episodes, improves ejection fraction, and decreases hospitalization.
منابع مشابه
Myocardial function, energy provision, and carnitine deficiency in experimental uremia.
Cardiac complications are the leading cause of mortality in patients with chronic renal failure. Secondary carnitine deficiency, which is frequently observed in hemodialysis patients, has been associated with cardiac hypertrophy and heart failure and may impair myocardial fatty acid oxidation. In chronic kidney disease, impaired carnitine homeostasis also may affect myocardial metabolism. In th...
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ورودعنوان ژورنال:
- Seminars in nephrology
دوره 26 1 شماره
صفحات -
تاریخ انتشار 2006